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new and highly specific gene expression patterns to different
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ously thought.Fo

s biol▓ogy and co-corresponding author of two of the three studies."We've

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in some sense established a ▓gold standard reference for how complex dif

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example for how to systematically reconstruct these types of processes," Klein said.NEW FINDINGSKlein's team used the CRISPR/Cas9 gene editing system t▓o create zebrafish with a mutant form of chordin, a gene involved i

n determining the back-to-front orientation of a developing embryo.Schier's team took a similar approach by profiling zebrafish with a mutation in a dif▓ferent patterning gene known as one-eyed pinhead.When analyzed with single-cell se▓quencing, the teams independently found that at

f replacing

the single-cell level, gene expression was the same in mutants and wildtype, despite the loss of an essential signaling pathway. The proportions of different cell types, however, changed.Also, when the researchers compared cell-

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formed in the embryo," said Allon Klein, ass